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1 Hashimoto s thyroiditis The thyroid gland is usually diffusely enlarged, firm, and finely nodular One thyroid lobe may be asymmetrically enlarged, raising concerns about neoplasm Although patients may complain of neck tightness, pain and tenderness are not usually present About 10% of cases are atrophic, the gland being fibrotic, particularly in elderly women Systemic manifestations are mostly related to ambient levels of thyroid hormone However, depression and chronic fatigue are more common in such patients, even after correction of hypothyroidism About one-third of patients have mild dry mouth (xerostomia) or dry eyes (keratoconjunctivitis sicca) of an autoimmune nature related to Sj gren s syndrome It may be associated with myasthenia gravis, which is usually of mild severity, mainly affecting the extraocular muscles and having a relatively low incidence of detectable AChR Ab or thymic disease Hashimoto s thyroiditis is sometimes associated with adrenal insufficiency (Schmidt s syndrome) and other endocrine deficiencies as part of polyglandular autoimmunity Thyroiditis is also more common in patients with other autoimmune conditions, such as inflammatory bowel disease or celiac disease (10%) Hashimoto s thyroiditis is very rarely associated with myocarditis, encephalopathy, or membranous
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Thyroiditis may be classified as follows: (1) chronic lymphocytic thyroiditis due to autoimmunity (also called Hashimoto s thyroiditis), (2) subacute thyroiditis, (3) suppurative thyroiditis, and (4) Riedel s thyroiditis Hashimoto s thyroiditis is an autoimmune condition and the most common thyroid disorder in the United States Elevated serum levels of antithyroid antibodies are found in 3% of men and 13% of women Women over the age of 60 years have a 25% incidence of elevated serum levels of antithyroid antibodies The incidence of Hashimoto s thyroiditis varies by kindred and by race; in persons older than 12 years
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