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Shortly after Chappe s inventions, American inventor and painter Samuel Morse (1791-1872) was the first to invent a practical electric telegraph in his painting atelier His first receiving instrument was constructed on a canvas stretcher frame A wooden clock motor provided the power to move a paper tape under a pen; in actuality, an electromagnet moved the pen, and was driven from the telegraph line The canvas stretcher provided a frame to support these devices, and on May 24th, 1844, Morse sent the famous words from the Bible, What hath God Wrought! on his telegraph from the US Capitol Building in Washington, DC, to the B70 Railroad Depot in Baltimore, Maryland Therein began one of the most important chapters in communications history; and a means of linking a vast continent about to experience rapid industrial expansion and Civil War (However, telegraphy is not actually wireless, even though it s about signaling and data Actually, electrical telegraphy relies on wireline transmission if someone cuts the wires, the transmissions end Still, the innovations in signaling and networks were vital for later wireless development; therefore telegraphy is still considered a mainstream source of components and ideas for the wireless signaling networks of today) Paralleling telegraphy developments were discoveries in electromagnetic science and radio In 1887 German Heinrich Hertz used periodic currents at very high frequency to demonstrate the existence of electromagnetic waves Hertz constructed the first spark-gap transmitter, a device that generated radio waves from an electrical spark Today, few people know of this particular invention but his name is mentioned millions of times everyday around the world, since it is used to measure frequency, as in microprocessor speed, eg, 14 GHz (giga Hertz) Hertz could not have foreseen the microprocessor, however, his work on frequency proved to be fundamental to future technology breakthroughs.

For instance, Lombardi rarely talked about injuries His explanation was insightful If you were with the Packers and were a sub, he once asked rhetorically, and if you read in the paper on Thursday that I had suggested that we were going to lose because the regular was unable to play because of injuries, how would you feel If I suggested we were going to lose because you were going to play, you would not feel very confident in yourself Success, in turn, brought more confidence, which brought more success You d be surprised, my father liked to say, how much confidence a little success will bring A great deal of that confidence originated from, and was invested in, the person of Vince Lombardi Halfback Paul Hornung, who knew my father better than most players, was a believer If Lombardi told me to move out wide on the next play, jump over the wall, run into the stands, and buy a program, Hornung once said, I would have thought it had some direct bearing on the play It might even score a touchdown My father s players believed in him Because of that, they also came to believe in themselves After all, that s who he believed in

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Note that the hydraulic pressure changes only slightly along the glomeruli; this is because the very large total cross-sectional area of the glomeruli collectively provides only a small resistance to flow Importantly, note that the oncotic pressure in the glomerular capillaries does change substantially along the length of the glomeruli Water is moving out of the vascular space and leaving protein behind, thereby raising protein concentration and, hence, the oncotic pressure of the unfiltered plasma remaining in the glomerular capillaries Mainly because of this large increase in oncotic pressure, the net filtration pressure decreases from the beginning of the glomerular capillaries to the end The average net filtration pressure over the whole length of the glomerulus is about 17 mm Hg This average net filtration pressure is higher than found in most nonrenal capillary beds Along with a high value for Kf , it accounts for the enormous filtration of 180 L of fluid/ day (compared with 3 L/day or so in all other capillary beds combined) As we have noted, the GFR is not fixed but shows marked fluctuations in differing physiological states and in disease If all other factors remain constant, any change in Kf , PGC , P BC , or GC will alter GFR However, all other factors do not always remain constant, and so other simultaneous events may oppose the effect of any one factor To grasp this situation, it is essential to see how a change in any one factor affects GFR under the assumption that all other factors are held constant Table 2 2 presents a summary of these factors It provides, in essence, a checklist to review when trying to understand how diseases or vasoactive chemical messengers and drugs change GFR In this regard, it should be noted that the major

His system, his success, was built on the premise that the players could do what he demanded of them He asked them to have confidence in him and his system, and together they would succeed

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