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acts to prevent changes in renal artery pressure from causing extreme changes in sodium delivery to the macula densa This mechanism acts in the opposite direction to the other reflexes and thus partially reduces or blunts their effectiveness However, the overall effect of an increase in renal artery pressure is still a net increase in sodium excretion (compare with Figure 7 10) GFR, glomerular filtration rate; PGC, hydrostatic pressure in glomerular capillaries

plicity of devices and networks, thus greatly simplifying the task for the application developer This is part of the value of using middleware in the design of a wireless data application Middleware, therefore, is generally needed and advisable when designing and building wireless applications

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Chuck Mercein, a fullback who played for my father in both Green Bay and Washington, made much of this notion He refuses to accept defeat, he once said, even when he is defeated I think he really believes that if the game goes on for another five minutes, he can win It makes a difference to play under a guy like that, I can tell you Obviously, the coach doesn t want a team that has just turned in a losing effort to walk home with its tail between its legs But I think there was something more to my father s attitude than simple spin-control I think he was giving a strong message to his players about dealing with adversity: What would we have done differently if the game had gone on another five minutes How would we have turned it around What should we do next time

The set of events just described is admittedly confusing, so the bottom line is this: high salt content in the thick ascending limb of a given nephron generates signals that reduce filtration in that nephron, thus blunting (but not eliminating) the tendency to raise sodium excretion initiated by other process in conditions (eg, volume expansion) where the appropriate overall response is increased sodium excretion

LOMBARDI ON TEACHING AND COACHING My father often used the words teaching and coaching interchangeably He was the coach of the Green Bay Packers; he was the teacher of the Green Bay Packers He was a molder of men, which applies equally to teachers and coaches

Figure 7 15 An example of tubuloglomerular feedback Changes in juxtaglomerular apparatus morphology during increasing tubular NaCl concentration from 25 (osmolality 5 210 mOsm/kg/H2O) to 135 mmol (osmolality 5 300 mOsm/kg/H2O) Macula densa cell (arrowhead) swelling and parallel swelling/contraction of cells in the final part of the afferent arteriole causes an almost complete closure of the arteriolar lumen (arrows), collapse of capillary loops (CAP), and shrinkage of the entire glomerulus (G) *, mesangial cells Bar 5 10 m (From Peti-Peterdi J et al, Am J Physiol Renal Physiol 2002;283:F197 Used with permission)

Whereas middleware used to refer principally to low-level translation functions in the protocol stack, today it enables applications development in an easy way with more high level functions Consequently, middleware provides a framework in which to build effective applications anything from bar code reading to messaging, calendar, office automation applications, or access to corporate directories, ERP systems, and the Internet Wireless middleware handles all aspects of wireless communication from security, to filtering, to compression, to dynamically rendering data for different devices This allows application developers to concentrate on their core business and not have to worry about understanding wireless or developing applications for each new device or network as they emerge The functions of wireless middleware can be broken down into three categories

To be the coach of a great football team, you ve got to be a good teacher Molder might be a better word The team must be molded into a unit, must have a character absolutely of its own, without, in any way, affecting the enormous value of personal aggressiveness of pride

Although there are several other renal mechanisms for controlling sodium balance independent of water balance, under normal physiological circumstances none is as important as aldosterone Only under certain pathophysiological conditions do these other mechanisms contribute significantly to the regulation of sodium balance

As both a teacher and a coach, Lombardi concentrated on the whys I never tell a player, This is my way, now do it, he once said Instead, I say, This is the way we do it, and this is why we do it Lombardi taught as he had taught many years before to his students at St Cecilia s He taught to the bottom of the class, going slowly enough and being repetitive enough so that no one

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