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Did the judge include a particular trial in the survey because the jury s verdict was consistent with the judge s Or because it was inconsistent Or simply because it was a recent case Certainly, different judges had different motivations, but this aspect of the procedure makes interpretation of the results more problematic Regardless, Kalven and Zeisel chose to focus on some of the possible reasons that jury verdicts sometimes differed from the judges hypothetical verdicts Under a category that they called jury sentiments (which accounted for at least half of the disagreements), they included acquittals by juries based on their feeling that the case was too trivial for formal review, plus acquittals based on a belief that the defendant had already suffered enough, as well as other non-evidentiary reactions to the defendant, the prosecution, and the legal system.

The shape of the resulting dimer will also presumably align imperfectly with EREs In either case, relatively few oestrogen-mimicking molecules actually trigger the cascade of oestrogenic effects which normally results from oestrogenic hormone exposure, and so the overall effect is muted Further information on the possible effects of oestrogens in the aquatic environment can be found in Stahlschmidt-Allner et al (1997) and useful reviews of the effects of pollutants on sh reproduction and reproductive behaviour can be found in Kime (1995) and Jones and Reynolds (1997) However, antioestrogenic environmental contaminants can act as weak antagonists at the ER, binding irreversibly with it but not producing dimers which can interact with the EREs They thus block the action of natural oestrogenic agonists, and the more receptors which are occupied, the weaker the action of the hormone will be.

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If we now write down the QR equations of Alg. 35.2 for these new variables, we arrive at the following statement. Define the normalized reflection coefficient

Your last step is to fade the title into Video Track 2: 1. Start by dragging the title image from the Project window to Video Track 2. Position the Title clip so that it begins after two seconds in the Timeline of the Statue of Liberty image in Video Track 1B.

An example of an oestrogen antagonist with therapeutic value is the drug tamoxifen which is used to treat or prevent breast cancer by blocking the potentiating effect of natural oestrogens Two different ER forms have been identi ed in mammals (Kuiper et al, 1996; Kuiper & Gustafsson, 1997), and possibly more forms occur in some sh species (Tchoudakova et al, 1999) A testicular ER has a higher af nity than the liver ER for oestrogens and xenoestrogens (Loomis & Thomas, 1999) Different tissues may therefore have different susceptibilities to chemical disruption There have been reports of some endocrine effects not mediated through ER binding and activation For example, -hexachlorocyclohexane ( -HCH) produced oestrogen-like responses (cell division and growth) at levels found in human breast cancer tissue (Steinmetz et al, 1996) Compounds, which do not bind ER (Coosen & van Velson, 1989; Steinmetz et al.

In contrast, judges verdicts were seen as sticking closer to the law and the weight of the evidence However, they noted that such sentiments were more likely to occur when, according to the judge, the evidence in the case was close and capable of supporting either verdict Thus they proposed a liberation hypothesis, arguing that the closeness of the evidence freed the jurors to give weight to their own feelings of justice (Kalven and Zeisel, 1966) The difference in the determinations of verdicts by judges and by juries re ects the expert-novice distinction that achieved some visibility in experimental psychology in the 1980s (Chi, Glaser and Farr, 1988) Experts are better able to discern the big picture and meaningful patterns in their areas of expertise, they can process information faster than can novices, and they see deeper implications of the material in their domain.

FIGURE 15.3 A ray of light impinging on the layer separating two mediums with different refraction indices.

, 1996), may promote DNA transcription and thus produce oestrogenic responses, by passing signals through a highway of hormone and non-hormone response elements that turn genes on (Steinmetz et al, 1996) For example, p,p -DDT, at or below levels found in human breast fat tissue, bypassed the oestrogen receptor and stimulated a complex mixture of cell signalling proteins (growth factor receptors) and processes that eventually led to cell division (Shen & Novak, 1997) Also, some super cially similar feminisation effects may be caused through antiandrogenic mechanisms whereby the masculinising action of testosterone or 11-ketotestosterone is blocked at the androgen receptor by androgen antagonists such as p,p -DDE (eg Kelce et al, 1995; see section 5131) These results suggest that the same chemical and/or its metabolites can in uence the endocrine system in more than one way.

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