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Recent work has demonstrated that the drug relaxes smooth muscle by modulating the movement of potassium ions involved in muscle action The discovery and subsequent development of another vasodilator, minoxidil, provides an almost textbook example of serendipity (Fig 12) In the early 1960s, scientists at Upjohn launched a screen aimed at nding compounds that lowered blood pressure in rats The wide variety of chemicals put through this screen was not restricted to entities synthesized by the company chemists Instead, they also included compounds obtained by browsing through commercial catalogues One of the early hits, di-allylmelamine, is a tonnage chemical This was, as the name suggests, closely related to one of the two components of melamine resins The synthesis program that was started to exploit this lead found that the molecule could be simpli ed and that one of the ring nitrogen atoms could be omitted.

Ring type: this is a CT though LV-designed to be installed on a medium voltage cable or on a bushing (see Figure 6-9).

Biologists were, however, puzzled by the lag time between administration of the simpli ed compound and the onset of action Detailed biochemical experiments revealed that passage through the liver added an oxygen atom to the molecule32 The antihypertensive activity of the rst administered compound was in fact due to this transformation product Scientists then started a program to produce modi cations of compounds related to the initial lead that now included the extra oxygen A closely related analogue of the metabolite was deemed more suitable for further development33 This compound was eventually granted the nonproprietary name minoxidil The suspicion, however, lurked in the minds of some Upjohn scientists that this oxide was still not the molecule responsible for the drug s antihypertensive.

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Fig. 7.4 Levels of spurs relative to signal (minus understood) for given LO and RF levels. The upper table is measured data and the lower table estimates values with the RF and LO levels given there.

Team decided to ask another board member and an administrator to join them on the search committee, as well as the chairperson of the fundraising committee.The organization will be richer in knowledge and more likely to implement the resulting recommendations if such leaders can work closely with the consultant. Be careful, however, that the group does not become unwieldy. The committee must remain small enough to work together as a cohesive unit.

for the stage in question. Thus an error in the value of R22 (k-) causes some error in overall noise factor due to the noise difference between the correct and erroneous values at that point in the circuit. In addition, R22 (k-) has some in uence on the preceding gain through ck , but these values will often be close to unity for circuits with output impedance that are small compared to the driven impedances. Figure A.3 is like Fig. 3.19 except the output resistances R22(k-) of the last three op amps are changed from 20 to 40 , and noise factors have been recomputed for those values. We can see, from cell H58, that this 2:1 change in assumed output impedance causes only 0.008 dB change in overall noise gure in this particular cascade, even though the noise gure of the last two ampli ers have changed nearly 3 dB. Figure A.4 shows that a change of 10% in source impedance for the rst op amp (cell E13) results in only a 0.03-dB change in overall noise gure for this example.

m=1 3 and i = 1 or i = 2 (e.g., pout,F 1 pout,F 2 or pout,F 1 ), is some product of output powers that depends on the particular IM or harmonic being considered. Here n indicates the order of the nonlinearity. We have dropped the designator H or IM; the development will apply to either. Compare to Eqs. (4.11), (4.12), (4.23), and (4.24). For the whole cascade this would be written n 1

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