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1 mals: many conclusions regarding the role of testosterone on penile erection have been drawn from experiments conducted in castrated rats; unfortunately this experimental paradigm is very different from the human situation, which is highly prevalent ie the ageing male with partial androgen de ciency syndrome due to age in males (PADAM) So far no reliable model of PADAM has been proposed Due to advances in molecular biology, genetically engineered mice have now become available Although the ultimate goal of these models is to develop gene therapy to rectify gene activity, transgenic or knockout mice have recently contributed to our understanding of the physiologic mechanisms of erectile function, as well as to various pathophysiologic processes occurring during ED

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receptor targeted by the compound under investigation the same in animals as compared to the human male and does it play the same role; eg intracavernosal prostaglandin E1(PGE1) injections do not elicit penile erection in many animal species When investigating the proerectile effect of pharmacologic compounds in animals, the following aspects must always be taken into account: dose used, route of administration, pharmacokinetics, half-life, metabolism of the studied compounds, etc

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As a result of adopting SFAS No 109, utilities adjusted their ADIT balances to the level obtained by multiplying the statutory tax rate by existing temporary differences Because this amount may be more or less than what has been permitted to be recovered through the rate-making process, regulatory assets or liabilities have also been recorded for nancial reporting purposes These regulatory assets and liabilities represent the future recovery or reduction in revenues as a result of previous income tax policies of regulatory commissions To illustrate the unique effects of utilities adopting SFAS No 109, two signi cant transactions will be described recording of amounts previously owed through as a reduction in customer rates and the effects of a change in tax rates 1 Recording of Amounts Previously Flowed Through SFAS No 109 requires utilities to record accumulated deferred taxes using the liability approach for all temporary differences whether normalized or owed through Accordingly, paragraph 18 of SFAS No 71 is superseded by SFAS No 109 Furthermore, the FASB has concluded that the asset (liability) created by a regulatory promise to allow recovery (or require a settlement) of ow-through amounts is best measured by the expected cash ow to be provided as the temporary difference turns around and is recovered (settled) in rates Thus, a regulatory asset or liability is established at the revenue requirement level, taking into account the tax-on-tax impact In the Statement, these regulatory assets/liabilities are characterized as probable future revenue/probable reduction in future revenue The corresponding ADIT liability represents the income taxes that would result in connection with recovering both the temporary difference itself and the newly recorded regulatory asset Accordingly, the computation of the amount to be recorded for prior ow-through is:

Add a new layer Call it mask It must be on top of all the other layers Zoom so you can see the entire Stage A zoom of 50% usually works Draw a filled rectangle the size fo the Stage Right-click (Win)/Ctrl-click (Mac) and choose mask from the menu The layer below border is indented on the list To include all the other layers in the mask, drag each of the other layers inward and slightly upward to indent it

Temporary differences owed through Gross-up (tax-on-tax) factor Tax rate Dr Regulatory asset/Cr ADIT liability

These experiments are conducted in the investigation of the local cellular mechanisms of penile erection Cavernosal strips from various animal species and humans have been studied in organ baths These tissues are either pharmacologically precontracted, eg with phenylephrine, or electrically stimulated (electrical eld stimulation) to elicit the release of neurotransmitters contained within the nerve terminals present in the tissue Numerous compounds (eg prostanoids, -adrenoceptor blockers, endothelin antagonists, PDE-5 inhibitors) have been found to be able to relax cavernosal strips by targeting various intracellular systems Primary cell cultures derived from animal or human corpus cavernosum have also been used as in vitro models to de ne cellular mechanisms involved in erectile function

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