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It is more difficult to see how and when Main Street develops for it has to mature to serve the broader and larger market beyond the early adopters In 5 we talked about the two drivers of wireless data: convenience and desire In the industries listed previously, the early wireless applications were desirable because they had a hard dollar return-on-investment Convenience in early markets is less a determining factor for the early adopters However, as time progresses, mainstream buyers will demand greater convenience where the business improvement can be obtained with less and less difficulty (See Figure 53) Although FedEx installed its own private radio network, as did IBM in the 1980s, the vast majority of corporations today must leverage existing networks Likewise, in some early installations, unique devices were designed and built to exacting specifications to meet the distinctive needs of the early customer Today, companies choose to use more standard networks, hardware, and operating systems to reduce their maintenance loads and the staff skills required to build and deploy wireless applications

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Fast PDF Compression Library for .NET | VeryDOC Knowledge Base
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The mechanisms responsible for matching changes in tubular reabsorption to changes in GFR are completely intrarenal (ie, glomerulotubular balance requires no external neural or hormonal input; indeed, the presence of such input usually obscures the existence of glomerulotubular balance, as described previously) Glomerulotubular balance is actually a second line of defense preventing changes in renal hemodynamics per se from causing large changes in sodium excretion The first line of defense is autoregulation of GFR, described in 2 and in the prior discussion of tubuloglomerular feedback GFR autoregulation prevents GFR from changing too much in direct response to changes in blood pressure, and glomerulotubular balance blunts the sodium-excretion response to whatever GFR change does occur Thus, tubuloglomerular feedback and glomerulotubular balance mediated by GFR autoregulation are processes that allow a large fraction of the responsibility for homeostatic control of sodium excretion to reside in those primary inputs that act to influence tubular reabsorption of sodium independently of GFR changes Before describing the mechanisms of long-term control in the next section we want to point out 2 key features of the renal handling of sodium First, interactions between the various mechanisms we have described thus far allow the kidneys to be true integrators of signals that are sometimes in conflict A good example is the case of prolonged aerobic exercise, specifically marathon running Well-trained, well-hydrated athletes running marathons on cool days (thus eliminating excessive loss of sodium as a confounding factor) exercise intensely for well over 2 h with an elevated blood pressure Systolic pressure is typically elevated by 50%, while MAP is elevated about 20% Acting alone this rise in pressure should induce vigorous pressure natriuresis But it does not If anything, renal excretion of sodium is decreased in these conditions because other signals override pressure natriuresis We also want to point out that all the mechanisms described so far lead to co-regulation of solute and water, ie, they tend by themselves to increase or decrease the excretion of sodium and water in exact parallel This is very effective as a coarse control over ECF volume However, sodium ingestion.

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Red Smith, the legendary sportswriter, once said that Lombardi s Packers were the smartest, most articulate athletes he had ever covered In part, this reflected the quality of the players Lombardi chose to be Packers But it was also a direct result of preparation Every play was explained thoroughly from each player s perspective: why it should be run a certain way and how the defense would react to the play This was no small task: Lombardi s passing attack (for example) was the most sophisticated in the game in the 60s He was one of the first coaches to teach his quarterback and receivers to read the defense and react accordingly My father believed that preparation for a football game was 80 percent physical and 20 percent mental This ratio, he also believed, reversed during the competition itself At that stage, it was 80 percent mental and 20 percent physical Football was a game played above the shoulders, he often said, which meant that you needed confidence, which meant in turn that you needed to be completely prepared

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Variation in GFR is a crucial determinant of renal function Everything else being equal, a higher GFR means greater excretion of salt and water Regulation of the GFR is straightforward in terms of physical principles but very complex functionally because there are so many regulated variables The rate of filtration in any of the body s capillaries, including the glomeruli, is determined by the hydraulic permeability of the capillaries, their surface area, and the net filtration pressure (NFP) acting across them

To play with confidence, a team must feel that everything possible has been done to prepare it fully for the coming game, and there is nothing more we can tell them

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