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2 Stimulates sodium reabsorption via a direct action on tubular cells (multiple receptors); one site affected is the proximal tubule 3 Stimulates afferent and efferent arteriolar constriction ( -adrenergic receptors) As a result: a GFR and RBF both decrease, the latter much more than the former b The increased renal resistance decreases PPC, and the increased filtration fraction increases PC These changes cause renal interstitial hydraulic pressure to decrease, which stimulates sodium reabsorption, mainly in the proximal tubule c The decreased GFR and the increased proximal sodium reabsorption (Effects 2 and 3b) result in decreased delivery of fluid to the macula densa, which causes increased renin secretion in addition to that of Effect 1 above

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Great teachers (and great coaches) win the hearts of their students They do so, Lombardi used to say, by selling themselves being involved right up to your neck and making that commitment clear You ve got to live it all day long, he once commented, in the car, at home, at night, looking at the pictures, out on the practice field In other words, Lombardi was also a salesman He sold himself to the team and the team to itself

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The three categories of renal nerve effects are listed in the order in which they are elicited as the frequency of renal nerve impulses is increased to higher and higher values Nore that the direct effects on both renin secretion and sodium reabsorption occur at lower stimulation levels than those required elicit renal vasoconstriction GFR, glomerular filtration rate; RBF, renal blood flow; PPC, peritubular-capillary hydralic pressure; PC peritubular capillary oncotic pressure

Coaching is selling Selling is teaching My customers are not so much the fans, but rather the players I have to first sell them on themselves, and then on the small hurts, because the small hurts are not only a part of football, but also a part of life And then I must sell them on this team, on this season, on this game, and each individual play as the most important thing in their lives

interconnected to deliver tangible benefits to a corporation A customer database can be linked to a web page, which is part of a new application to provide a clothing catalog s customers the ability to order clothes on the web The same database can be used by several other applications, such as billing and customer profiling, since the customer database contains basic data about customers This re-purposing or re-use of resources makes information technology very powerful Upon inspection it also proves that new technologies tend to be incremental to existing technologies, adding value to what currently exists When the web blasted onto the scene in the mid-1990s, web front-ends were placed in front of existing applications (dubbed legacy applications) making the web incrementally valuable It did not, as many technology zealots predicted, replace all other forms of computing or communication, rather it proved to be another useful channel for these activities Society experienced a dramatic example of this re-use during the latter half of the 1990s In that short period of time, practically every company on the planet provided their customers with web-based information and applications This tremendous spurt in application growth was made possible in part by the re-use of existing non-web server resources In many cases, the new web applications were created by placing a web graphical user interface in front of the old non-web application Likewise for wireless applications, many current non-wireless applications can be re-used or redeployed with wireless devices by providing a wireless adaptation Middleware integrates tightly with existing enterprise applications, allowing companies to leverage existing resources, rather than having to build all new applications that need to be separately maintained Many middleware providers support delivering web content to browser-based devices Ideally middleware should support access to applications and web content from browsers and devices with intelligent client applications.

Table 7 3 Changes in these factors influence sodium excretion in response to changes in plasma volume

Pat Fischer, defensive back for the Redskins, developed a clear insight into Lombardi s teaching and coaching techniques

Filtration of sodium GFR Plasma sodium concentration (of minor importance except in severe disorders) Tubular reabsorption of sodium Arterial blood pressure effects on proximal reabsorption (pressure natriuresis) Aldosterone Peritubular capillary factors, acting via RIHP Renal nerves (direct tubular effects and indirect effects via angiotensin II and RIHP) Angiotensin II (direct tubular effects and indirect effect via RIHP) GFR (glomerulotubular balance) Atrial natriuretic factor Antidiuretic hormone

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