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While this concept enables the network to transfer data to a user much faster then before, there are still a number of shortcomings that have been solved by UMTS With GPRS, it is only possible to bundle timeslots on a single carrier frequency Therefore, it is theoretically possible to bundle up to eight timeslots In an operational network, however, it is rare that a mobile station can bundle more than four timeslots, as some of them are also necessary for voice calls of other users Furthermore, on the terminal side today, most phones can only handle four timeslots at a time in the downlink direction This is because bundling more timeslots would require more complex hardware in the mobile station A GSM base station was initially designed for voice traffic, which only requires a modest amount of transmission capacity.

4 See http://java.sun.com/products/personaljava for details about the Personal Java Application Environment 5 See http://java.sun.com/products/javaphone for more information 6 See http://java.sun.com/products/cldc for more information 7 See http://java.sun.com/products/midp for more information

This is why GSM base stations are usually connected to the BSC via a single 2 Mbit/s E-1 connection Depending on the number of carrier frequencies.

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in the next few years in reference laboratories Physicians will not be expected to understand the methods and the patterns Instead, physicians will be expected to utilize the interpretations provided from these laboratories, as with classical pathology and with exotic nongenetic tests, to characterize the stage of disease in patients with cancers and to assist in directing therapy for a host of conditions Patients will rely on their physicians for such interpretations Chips already exist with numerous known mutations of the various relevant CYP enzymes; other potentially useful polymorphisms could be added to such chips for automated analyses The choice of drug therapy in large B cell lymphoma may be guided now by the patterns of gene expression reported by Alizadeh et al (2000).

Electroencephalogram (EEG) may be abnormal with random, high-voltage slow waves and spikes that arise from multiple foci and spread to various cortical areas (Curatolo et al, 2008; J Jacobs et al, 2008; Leal et al, 2008); over time, the pattern of electrical discharge develops into the more rhythmic activity associated with seizures (J Jacobs et al, 2008) Seizures initially may manifest as infantile spasms with gradual development into seizures in adolescence and adulthood; these seizures frequently do not improve with typical antiepileptic drugs (Curatolo et al, 2008) The primary medical complication is epilepsy, but there also is potential for related health problems that affect kidneys, heart, lungs, and bone (Baskin, 2008) The extent of medical involvement is highly variable and may present prior to or precipitate the identi cation of tuberous sclerosis.

The Input API, input.h, provides information on the states and state changes of input devices, such as the embedded keypad and four-way controller, and external input devices connected to the phone via USB or Bluetooth wireless technology. The Text Input API, textinput.h, handles text input on keypads in multi-tapping, predictive text input and numeric modes. It supports Western typing and the stroke, Shuyin, and Pinyin Chinese text input systems. The Keypad Capabilities API, input.h and runtime.h, provides an interface to retrieve general information about the default keypad device connected to the phone, such as a list of the physical keys it supplies and the default action keys in its supported orientations.

The possibility that women with BRCA1 respond differently than women with BRCA2 to treatment with tamoxifen or other selective estrogen receptor modulators, based on very preliminary clinical epidemiological observations (King et al, 2001), seems ripe for molecular pharmacogenomic investigation If this is true, prevention with these agents might be recommended differentially Physicians addressing patients with suspected environmental, occupational, or recreational exposures to particular agents may be able to submit blood samples or tissue biopsies to special laboratories of toxicogenomics to assay for evidence of molecular signatures of particular exposures and possibly for inherited susceptibility to adverse effects from such exposures Of course, nongenetic factors nutrition, smoking, alcohol, other pharmaceutical, nutraceutical, and chemical exposures, infections, physical activity, age, gender, menstrual cycle, and body mass index will have to be evaluated knowledgeably to understand, let alone predict, ef cacy and toxicity.

The power of prediction from screening tests (see Lave and Omenn Value-ofInformation Model, 1986, 1988) is always less than 100% for either positive predictive value or negative predictive value, or, generally, for both, often much less (Holtzman and Marteau, 2000; Holtzman, 2003) That de ciency is true for all kinds of tests in medicine and public health, whether biochemical or physiological, including the use of the electrocardiogram as a test for risk of heart attack For the near term, it is certain that pharmacogenomics will be utilized in characterizing tumors and choosing therapies for multiple cancers, as described above Oncology is clearly leading the way among clinical elds, although many other elds and diseases will be generating evidence from microarray and proteomics research studies Much of cancer care is managed by specialists, especially because of the complexity of treatments and the toxicity of potent drugs.

M. Gibson, Pharmaceutical Formulation and Preformulation, CRC Press, Boca Raton, FL, 1998.

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