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Endemic goiters may become multinodular and very large Growth often occurs during pregnancy and may cause compressive symptoms
individuals with autonomous multinodular goiters; therefore, levothyroxine suppression should not be started in patients with suppressed TSH levels Adults with large multinodular goiter may require thyroidectomy for cosmesis, compressive symptoms, or thyrotoxicosis Following partial thyroidectomy in iodinedeficient geographic areas, there is a high goiter recurrence rate, so total thyroidectomy is preferred when surgery is indicated Certain patients may be treated with 131I for large compressive goiters; rarely, Graves' disease may develop 3 10 months after treatment
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Bellantone R et al Predictive factors for recurrence after thyroid lobectomy for unilateral non-toxic goiter in an endemic area: results of a multivariate analysis Surgery 2004 Dec;136(6): 1247 51 [PMID: 15657583] Valentino R et al Screening a coastal population in Southern Italy: iodine deficiency and prevalence of goitre, nutritional aspects and cardiovascular risk factors Nutr Metab Cardiovasc Dis 2004 Feb;14(1):15 9 [PMID: 15053159]
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Substernal goiters are usually asymptomatic but can cause tracheal compression, respiratory distress and failure, dysphagia, superior vena cava syndrome, gastrointestinal bleeding from esophageal varices, palsies of the phrenic or recurrent laryngeal nerves, or Horner s syndrome Cerebral ischemia and stroke can result from arterial compression or thyrocervical steal syndrome Substernal goiters can rarely cause pleural or pericardial effusions The incidence of significant malignancy is less than 1% Some patients with endemic goiter may become hypothyroid Others may become thyrotoxic as the goiter grows and becomes more autonomous, especially if iodine is added to the diet
The serum T4 is usually normal Serum TSH is generally normal TSH falls in the presence of hyperthyroidism if a multinodular goiter has become autonomous in the presence of sufficient amounts of iodine for thyroid hormone synthesis TSH rises with hypothyroidism Thyroid RAI uptake is usually elevated, but it may be normal if iodine intake has improved Serum levels of antithyroid antibodies are usually either undetectable or in low titers Serum thyroglobulin is often elevated
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Parathyroid hormone (PTH) increases osteoclastic activity in bone, increases the renal tubular reabsorption of calcium, and stimulates the synthesis of 1,25-dihydroxycholecalciferol by the kidney Meanwhile, PTH inhibits the absorption of phosphate and bicarbonate by the renal tubule All of these actions cause a net increase in serum calcium
Endemic goiter must be distinguished from all other forms of nodular goiter that may coexist in an endemic region (see above)
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Iodine deficiency is prevented by adding potassium iodide to commercial salt, about 20 mg/kg salt Iodized salt has greatly reduced the incidence of endemic goiter Unfortunately, many iodine-deficient countries have inadequate programs for iodine supplementation The minimum dietary requirement for iodine is about 50 mcg daily, with optimal iodine intake being 150 300 mcg daily Iodine sufficiency is assessed by measurement of urinary iodide excretion, the target being more than 10 mcg/dL Initiating iodine supplementation in a geographic area causes an increased frequency of hyperthyroidism in the first year, followed by greatly reduced rates of toxic nodular goiter and Graves disease thereafter
Tetany, carpopedal spasms, tingling of lips and hands, muscle and abdominal cramps, psychological changes Positive Chvostek s sign and Trousseau s phenomenon Serum calcium low; serum phosphate high; alkaline phosphatase normal; urine calcium excretion reduced Serum magnesium may be low
The addition of potassium iodide to table salt greatly reduces the prevalence of endemic goiter and cretinism but is less effective in shrinking established goiter Concurrent deficiencies in both vitamin A and iodine increase the risk of endemic goiter and concurrent repletion of both iodide and vitamin A reduces goiter in endemic goiter regions Dietary iodine supplementation increases the risk of autoimmune thyroid dysfunction, which may result in hypothyroidism or thyrotoxicosis Excessive iodine intake may increase the risk of goiter Levothyroxine supplementation can shrink goiters and reduce the risk of further goiter growth, but such treatment carries a risk of inducing hyperthyroidism in
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